This product is free for those who attended FNCE® 2018.
Healthy aging can be described as the pursuit to possess a biological age equal to or younger than your chronological age. Of critical importance to healthy aging is the maintenance of skeletal muscle, as it encompasses a large portion (~40%) of whole-body mass essential for force output and daily functioning (e.g., rising from a chair or climbing stairs). It also contains the largest storage site for glucose disposal and regulates glucose homeostasis. Thus, this organ is vital for not only physical independence but protecting against a host of metabolic diseases such as obesity, insulin resistance and diabetes, cachexia, and cardiovascular disease.
Sarcopenia, first coined by Dr. Irwin Rosenberg in 1988, is the involuntary loss of skeletal muscle mass with age, which has become pronounced in recent times due to an increase in life expectancy. Sarcopenia manifests between the fourth and fifth decades of life, and rapidly increases at the eighth. The changes that occur with sarcopenia are profound; after the age of ~40 years, skeletal muscle loss occurs at a rate of ~1-3% annually, thereafter increasing to ~3-6% per annum at age ~80. The pathophysiological alterations contributing to sarcopenia are multifactorial, including a reduction in neuromuscular drive (loss of muscle motor unit size/number and specific fiber types), net loss of muscle proteins during metabolism, withdrawal of anabolic hormones from the endocrine system, and an increase in intramuscular adipose tissue accompanied by chronic low-grade inflammation. Together, or in some cases singularly, these mechanisms affect muscle strength and power, which are both adversely associated with falls/fractures in older adults.
Thankfully, however, emerging evidence shows exercise and dietary-protein, either combined or independently, may offset the deleterious effects of sarcopenia. This talk will focus on this evidence.
CPE Level: 3
Learning Codes: 3020, 7070, 7120
- Identify the key physiological mechanisms that regulate skeletal muscle metabolism.
- Describe the multifactorial pathology of sarcopenia.
- Describe the synergistic role of exercise and dietary-protein feeding to counteract sarcopenia.
- Ben Kirk, BSc (Hons), MSc
- Katherine Dodd, MS, RDN, CSG, LD, FAND
Planned with the Committee for Lifelong Learning