216. Influence of Diet and Body Composition on Thyroid Hormone Regulation

FNCE Recorded Sessions from 2017

Thyroid hormones are primarily responsible for the regulation of metabolism.

  • SKU FNCE17216
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This product is free for those who attended FNCE® 2017.

Thyroid hormones are primarily responsible for the regulation of metabolism. Specifically, the pro-hormone thyroxine (T4) is converted to triiodothyronine (T3) via the type 1 and type 2 deiodinases. In turn, T3 drives energy expenditure via generation and maintenance of ion gradients, regulation of heart rate and cardiac output, and the stimulation of glucose metabolism, protein synthesis and lipolysis. Recent evidence in animal and cell models has suggested that thyroid hormone activity is modulated by nutrient availability; specifically the 2 deiodinases activated downstream of the PI3K-mTORC2-Akt pathway. Interestingly, body composition may also influence T3 levels. This session will discuss how alterations in leptin and leptin signaling can interfere with thyroid metabolism, review the role of calorie intake and muscle and fat depots on thyroid function, and describe the role of diet therapy to regulate thyroid hormone levels among individuals with hypothyroidism.

CPEU: 1.5
CPE Level: 3
Learning Codes: 2100, 2070, 3030

Learning Objectives

  • Summarize the influence of type 1 and type 2 deiodinases activity on thyroid metabolism.
  • Examine the influence of nutrient availability and activation of the PI3K-mTORC2-Akt pathway on type 2 deiodinases activity.
  • Describe how body composition can effect thyroid hormone activity.


  • Antonio Bianco, PhD, MD


  • Lattoya Lartey , PhD
  • Sarah Peterson, PhD, RD, LDN, CNSC
  • SKU FNCE17216