Last published in 2012, the 2022 Nutrition and Physical Activity Guideline for Cancer Survivors addresses nutrition and physical activity recommendations during the continuum of cancer care. A growing body of evidence suggests that diet, physical activity, and obesity affect risk for recurrence and overall survival following a cancer diagnosis. The purpose of this timely guideline is to provide evidence-based, cancer-specific recommendations for anthropometric parameters, physical activity, diet, and alcohol intake for reducing recurrence and cancer-specific and overall mortality. The guideline is intended to serve as a resource for informing healthcare teams, oncology programs, health policy, and survivors. It also includes information on the relationship between health-related behaviors and co-morbidities, long-term sequelae and patient-reported outcomes, and health equities with attention to enabling survivors' ability to adhere to recommendations. Approaches to meet survivors' needs are addressed, as well as clinical care coordination and resources for nutrition and physical activity counseling after a cancer diagnosis.