This publication is dedicated to looking at medication approaches beyond glucose lowering, starting with a guideline update overview that focuses on medications which do more than just lower glucose. The following topics will be discussed:

• Real-world influences on diabetes self-management including medication adherence, perception of illness, cultural beliefs, religious and/or spiritual beliefs, knowledge of their condition, and social determinants of health.
• An update on new indications and expansions of current therapies, as well as new medications expected to be approved in the near future.
• The background, interchangeability, and use of biosimilar insulins.
• Strategies for dosing insulin with regard to food and weight loss therapies that double-dip as glucose lowering agents.
• Common over-the-counter (OTC) products and their use for people with diabetes.