This webinar was presented live on May 11, 2022.
CPE Level: 3
Presentation 1: Biomarkers of Nitrite, Nitrate, and Nitric Oxide Status in Athletes
Nitric oxide controls and regulates blood flow and oxygen delivery to every cell in the body. This simple molecule also controls mitochondrial function and ATP production. Consequently, it has become extremely important in sports performance. Inorganic nitrate found in green leafy vegetables and beets has gained popularity as an ergogenic aid in many athletes. However, the data are equivocal at best on the benefits of beets and/or nitrate for improving performance. The complex pathway to metabolize inorganic nitrate to nitrite and nitric oxide may explain the mixed results in clinical trials. Firstly, there is a wide variation in the amount of nitrate found naturally in vegetables and in commercial products. Secondly, nitrate reducing bacteria in the oral cavity are required for nitrate metabolism. Thirdly, stomach acid is required to convert salivary nitrite to nitric oxide in the gastric lumen. Therefore, any studies that do not quantify nitrate or account for mouthwash use, antibiotic use or antacid use will not yield positive results. This lecture will elucidate the pathways of production of nitric oxide and understand what goes wrong is people that cannot make nitric oxide and then reveal safe and effective strategies to restore nitric oxide production to optimize human nutrition and enhance performance.
Nathan S. Bryan, PhD
Dr. Nathan S. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean's Award for Excellence in Research. He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute. After a two year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology. Dr. Bryan has been involved in nitric oxide research for the past 20 years and has made many seminal discoveries in the field. His many seminal discoveries have resulted dozens of issued US and International patents and the product technology resulting from his discoveries and inventions has improved patient care worldwide. Dr. Bryan is a successful entrepreneur and Founder of HumanN, Inc, Pneuma Nitric Oxide, LLC, Nitric Oxide Innovations, LLC and Bryan Nitriceuticals, LLC. His product technology is responsible for hundreds of millions of product sales worldwide. Most recently, Dr. Bryan serves as Founder and CEO of Nitric Oxide Innovations, LLC, a privately-held, clinical-stage biopharmaceutical company that is actively engaged in the discovery and development of nitric oxide based therapies. Their lead drug candidate NOviricid is currently in phase 3 clinical trials for the treatment of COVID19 in African Americans and Hispanics. Dr. Bryan is an international leader in molecular medicine and nitric oxide biochemistry.
Presentation 2: Biomarkers of Bone Health in Athletes
Exercise has been shown to have both acute and long-term effects on the skeleton, and bone biomarkers are one way to assess changes in skeletal health in athletes. This session will provide an overview of currently used bone biomarkers, the effects of diet and/or exercise on bone biomarkers, and a discussion on the current recommendations for the timing and frequency of testing. Consideration will be given for different kinds of sports (e.g., strength and power versus endurance) and exercise intensity.
Sarah Wherry, PhD
Dr. Sarah Wherry received her BS in Life Science from Penn State, her MS in Sports Nutrition and Exercise Science from Marywood University, and her PhD in Exercise and Nutritional Sciences from Arizona State University. She completed her postdoctoral fellowship in the Integrative Physiology of Aging at the University of Colorado Anschutz Medical Campus, and she is currently an Assistant Professor in the Division of Geriatric Medicine at the University of Colorado Anschutz Medical Campus. Her research interests include the bone biomarker response to exercise in young and older adults, including the effects of exercise training, mode, and intensity.